Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora.

نویسندگان

  • Hyo Jin Kim
  • Eun Ju Chang
  • Sung Hee Cho
  • Shin Kyo Chung
  • Heui Dong Park
  • Sang Won Choi
چکیده

Seven stilbenes, a new cis-epsilon-viniferin and the six known stilbenes, trans-resveratrol, trans-resveratrol-4'-O-beta-D-glucopyranoside, trans-epsilon-viniferin, gnetin H, and suffruticosol A and B, were isolated and identified from seeds of Paeonia lactiflora. The antioxidative activity of these stilbene derivatives was evaluated against the 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by the hydroxyl radical generated via a Fenton-type reaction. Among these stilbenes, trans-epsilon-viniferin and gnetin H significantly inhibited 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. In addition, cis-epsilon-viniferin, and suffruticosol A and B also exhibited moderate antioxidative activity. These results suggest that resveratrol dimers and trimers, together with resveratrol from seeds of Paeonia lactiflora may be useful as potential sources of natural antioxidants.

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عنوان ژورنال:
  • Bioscience, biotechnology, and biochemistry

دوره 66 9  شماره 

صفحات  -

تاریخ انتشار 2002